disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate
carbenoxolone disodium
CAS: 7421-40-1
Molecular Formula: C34H48Na2O7
disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate - Names and Identifiers
| Name | carbenoxolone disodium |
| Synonyms | 20-beta)-3-bet CARBENOXOLONE SODIUM carbenoxolone disodium CARBENOXOLONE DISODIUM SALT disodiumglycyrrhetinylsuccina 18-beta-glycyrrhetinicacidhydrogensuccinate,disodiumsalt 3-beta-hydroxy-11-oxoolean-12-en-30-oicacidhydrogensuccinate,disodiumsal disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate 3-o-(beta-carboxypropionyl)-11-oxo-18-beta-olean-12-en-30-oicacid,disodium (3BETA-HYDROXY-11-OXOOLEAN-12-EN-30-OIC ACID 3-HEMISUCCINATE) DISODIUM SALT disodium 4-(20-carboxylato-11-oxo-30-beta-norolean-12-en-3-yloxy)-4-oxobutyrate disodium (3beta,8xi,10xi,17xi,18xi)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate |
| CAS | 7421-40-1 |
| EINECS | 231-044-0 |
| InChI | InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33+,34+;;/m0../s1 |
disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate - Physico-chemical Properties
| Molecular Formula | C34H48Na2O7 |
| Molar Mass | 614.72 |
| Melting Point | >275°C (dec.) |
| Boling Point | 687.4°C at 760 mmHg |
| Flash Point | 211.6°C |
| Water Solubility | Soluble in water to 100 mM. |
| Solubility | Soluble in water to 100 mM. |
| Vapor Presure | 1.06E-20mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | pKa1 4.18; pKa2 5.52(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Hygroscopic |
| MDL | MFCD00079043 |
| Use | Used as an anti-ulcer drug |
disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | RK0250000 |
| Toxicity | LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan) |
disodium (3beta)-3-[(3-carboxylatopropanoyl)oxy]-11-oxoolean-12-en-30-oate - Reference Information
| biological activity | Carbenoxolone diisodium is an active metabolite of glycyrrhizic acid (HY-N0184) and human 11 β-hsd and bacterial 3α, inhibitors of 20 β-HSD. Carbenox one diisodium is a gap junctions and can effectively inhibit the growth of vaccinia Virus. Carbenqol diisodium can be used to study the related research of digestive, esophageal and oral ulcers and inflammation. |
| Target | IC50: human 11 β-HSD; bacterial 3 α, 20 β-HSD; gap junction; vaccinia virus |
| Cell Line: | HaCaT cells HaCaT cells |
| Concentration: | 6 μM, 12 μM, 30 μM, 60 μM, 150 μM 30 μM |
| Incubation Time: | Pre-treatment 1 hour Pre-treatment 1 hour |
| Result: | Had no toxicity until 48 hours at high dose in virus-infected cells. Presented an obvious upregulation of A27. Significantly increased the sleeping time in mice. |
| Animal Model: | Male BALB/c mice |
| Dosage: | 100, 200 and 300 mg/kg |
| Administration: | Intraperitoneal injection; 30, 60 and 60 min before Pentylenetetrazole |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 2450 mg/kg; Intraperitoneal-mouse LD50: 120 mg/kg |
| flammability hazard characteristics | toxic sodium oxide fumes from thermal decomposition |
| storage and transportation characteristics | low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, dry powder |
Last Update：2024-04-09 02:00:11
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Product Name: Carbenoxolone Disodium Visit Supplier Webpage Request for quotationCAS: 7421-40-1
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